In Vitro Cytotoxic Activity Toward Anticancer and Antimicrobial of Azadirachta Indica, Aegle Marmelos, Ocimum Sanctum and Withania Somnifera Extracts

Rajeev Nema; Sarita Khare

doi:doi:10.11648/j.be.20200402.11

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In Vitro Cytotoxic Activity Toward Anticancer and Antimicrobial of Azadirachta Indica, Aegle Marmelos, Ocimum Sanctum and Withania Somnifera Extracts

Rajeev Nema, Sarita Khare

Published in Bioprocess Engineering (Volume 4, Issue 2)

Received: 31 May 2019 Accepted: 17 September 2020 Published: 30 September 2020

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Abstract

Background: Resistance to treatment represents the ‘big’ problem and the considerable improvement in survival rates still remains a researcher’s dream. Thus, continued research efforts are required to make treatments more personalized, to minimize side effects and improve overall survival and to also have an insight in toxico-genomics. Indeed proof of facts about medicinal plants worldwide and rich Indian medicinal flora, Objective: in the present investigation attempts to evaluate antimicrobials and anticancer therapeutic properties of isolated constituents from Withania somnifera (ASHWANGANDHA) Part Used Leaves, Aegle marmeleos (BEL) Part Used Leaves, Azadirachta indica (NEEM) Part Used Leaves, Ocimum sanctum (TULASI) Part Used Leaves, Method: Hydro alcoholic (1:1) Extracts were evaluated against cancer cell lines i.e. A549 (Lung carcinoma), PA-1 (Ovarian cancer) and MCF-7 (Breast cancer), with standard as Doxorubicin. Moreover the antimicrobial activity on Staphylococcus aureus, Bacillus coagulans and one Gram-negative—Escherichia coli, human pathogenic bacteria; and three fungal strains—Aspergillus niger, Tricoderma viride and Fusarium oxysporum. Result: The results showed significant association of phytochemicals on inhibition of test bacteria and fungi with significant p value p< 0.05, except For Tricoderma viride No Association Was Found P>0.05.

Published in	Bioprocess Engineering (Volume 4, Issue 2)
DOI	10.11648/j.be.20200402.11
Page(s)	40-46
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

In Vitro Anticancer Antibacterial, Antifungal, Aegle Marmeleos, Azadirachta Indica, Ocimum Sanctum and Withania Somnifera

References

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APA Style

Rajeev Nema, Sarita Khare. (2020). In Vitro Cytotoxic Activity Toward Anticancer and Antimicrobial of Azadirachta Indica, Aegle Marmelos, Ocimum Sanctum and Withania Somnifera Extracts. Bioprocess Engineering, 4(2), 40-46. https://doi.org/10.11648/j.be.20200402.11

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ACS Style

Rajeev Nema; Sarita Khare. In Vitro Cytotoxic Activity Toward Anticancer and Antimicrobial of Azadirachta Indica, Aegle Marmelos, Ocimum Sanctum and Withania Somnifera Extracts. Bioprocess Eng. 2020, 4(2), 40-46. doi: 10.11648/j.be.20200402.11

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AMA Style

Rajeev Nema, Sarita Khare. In Vitro Cytotoxic Activity Toward Anticancer and Antimicrobial of Azadirachta Indica, Aegle Marmelos, Ocimum Sanctum and Withania Somnifera Extracts. Bioprocess Eng. 2020;4(2):40-46. doi: 10.11648/j.be.20200402.11

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@article{10.11648/j.be.20200402.11,
  author = {Rajeev Nema and Sarita Khare},
  title = {In Vitro Cytotoxic Activity Toward Anticancer and Antimicrobial of Azadirachta Indica, Aegle Marmelos, Ocimum Sanctum and Withania Somnifera Extracts},
  journal = {Bioprocess Engineering},
  volume = {4},
  number = {2},
  pages = {40-46},
  doi = {10.11648/j.be.20200402.11},
  url = {https://doi.org/10.11648/j.be.20200402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.be.20200402.11},
  abstract = {Background: Resistance to treatment represents the ‘big’ problem and the considerable improvement in survival rates still remains a researcher’s dream. Thus, continued research efforts are required to make treatments more personalized, to minimize side effects and improve overall survival and to also have an insight in toxico-genomics. Indeed proof of facts about medicinal plants worldwide and rich Indian medicinal flora, Objective: in the present investigation attempts to evaluate antimicrobials and anticancer therapeutic properties of isolated constituents from Withania somnifera (ASHWANGANDHA) Part Used Leaves, Aegle marmeleos (BEL) Part Used Leaves, Azadirachta indica (NEEM) Part Used Leaves, Ocimum sanctum (TULASI) Part Used Leaves, Method: Hydro alcoholic (1:1) Extracts were evaluated against cancer cell lines i.e. A549 (Lung carcinoma), PA-1 (Ovarian cancer) and MCF-7 (Breast cancer), with standard as Doxorubicin. Moreover the antimicrobial activity on Staphylococcus aureus, Bacillus coagulans and one Gram-negative—Escherichia coli, human pathogenic bacteria; and three fungal strains—Aspergillus niger, Tricoderma viride and Fusarium oxysporum. Result: The results showed significant association of phytochemicals on inhibition of test bacteria and fungi with significant p value pTricoderma viride No Association Was Found P>0.05.},
 year = {2020}
}

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TY  - JOUR
T1  - In Vitro Cytotoxic Activity Toward Anticancer and Antimicrobial of Azadirachta Indica, Aegle Marmelos, Ocimum Sanctum and Withania Somnifera Extracts
AU  - Rajeev Nema
AU  - Sarita Khare
Y1  - 2020/09/30
PY  - 2020
N1  - https://doi.org/10.11648/j.be.20200402.11
DO  - 10.11648/j.be.20200402.11
T2  - Bioprocess Engineering
JF  - Bioprocess Engineering
JO  - Bioprocess Engineering
SP  - 40
EP  - 46
PB  - Science Publishing Group
SN  - 2578-8701
UR  - https://doi.org/10.11648/j.be.20200402.11
AB  - Background: Resistance to treatment represents the ‘big’ problem and the considerable improvement in survival rates still remains a researcher’s dream. Thus, continued research efforts are required to make treatments more personalized, to minimize side effects and improve overall survival and to also have an insight in toxico-genomics. Indeed proof of facts about medicinal plants worldwide and rich Indian medicinal flora, Objective: in the present investigation attempts to evaluate antimicrobials and anticancer therapeutic properties of isolated constituents from Withania somnifera (ASHWANGANDHA) Part Used Leaves, Aegle marmeleos (BEL) Part Used Leaves, Azadirachta indica (NEEM) Part Used Leaves, Ocimum sanctum (TULASI) Part Used Leaves, Method: Hydro alcoholic (1:1) Extracts were evaluated against cancer cell lines i.e. A549 (Lung carcinoma), PA-1 (Ovarian cancer) and MCF-7 (Breast cancer), with standard as Doxorubicin. Moreover the antimicrobial activity on Staphylococcus aureus, Bacillus coagulans and one Gram-negative—Escherichia coli, human pathogenic bacteria; and three fungal strains—Aspergillus niger, Tricoderma viride and Fusarium oxysporum. Result: The results showed significant association of phytochemicals on inhibition of test bacteria and fungi with significant p value pTricoderma viride No Association Was Found P>0.05.
VL  - 4
IS  - 2
ER  -

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Author Information

Rajeev Nema

Department of Biochemistry, All India Institute of Medical Sciences (AIIMS) Bhopal, Saket Nagar, Bhopal, India
Sarita Khare

Government MLB Girls PG College, Bhopal, Madhya Pradesh, India

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APA Style

Rajeev Nema, Sarita Khare. (2020). In Vitro Cytotoxic Activity Toward Anticancer and Antimicrobial of Azadirachta Indica, Aegle Marmelos, Ocimum Sanctum and Withania Somnifera Extracts. Bioprocess Engineering, 4(2), 40-46. https://doi.org/10.11648/j.be.20200402.11

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ACS Style

Rajeev Nema; Sarita Khare. In Vitro Cytotoxic Activity Toward Anticancer and Antimicrobial of Azadirachta Indica, Aegle Marmelos, Ocimum Sanctum and Withania Somnifera Extracts. Bioprocess Eng. 2020, 4(2), 40-46. doi: 10.11648/j.be.20200402.11

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AMA Style

Rajeev Nema, Sarita Khare. In Vitro Cytotoxic Activity Toward Anticancer and Antimicrobial of Azadirachta Indica, Aegle Marmelos, Ocimum Sanctum and Withania Somnifera Extracts. Bioprocess Eng. 2020;4(2):40-46. doi: 10.11648/j.be.20200402.11

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@article{10.11648/j.be.20200402.11,
  author = {Rajeev Nema and Sarita Khare},
  title = {In Vitro Cytotoxic Activity Toward Anticancer and Antimicrobial of Azadirachta Indica, Aegle Marmelos, Ocimum Sanctum and Withania Somnifera Extracts},
  journal = {Bioprocess Engineering},
  volume = {4},
  number = {2},
  pages = {40-46},
  doi = {10.11648/j.be.20200402.11},
  url = {https://doi.org/10.11648/j.be.20200402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.be.20200402.11},
  abstract = {Background: Resistance to treatment represents the ‘big’ problem and the considerable improvement in survival rates still remains a researcher’s dream. Thus, continued research efforts are required to make treatments more personalized, to minimize side effects and improve overall survival and to also have an insight in toxico-genomics. Indeed proof of facts about medicinal plants worldwide and rich Indian medicinal flora, Objective: in the present investigation attempts to evaluate antimicrobials and anticancer therapeutic properties of isolated constituents from Withania somnifera (ASHWANGANDHA) Part Used Leaves, Aegle marmeleos (BEL) Part Used Leaves, Azadirachta indica (NEEM) Part Used Leaves, Ocimum sanctum (TULASI) Part Used Leaves, Method: Hydro alcoholic (1:1) Extracts were evaluated against cancer cell lines i.e. A549 (Lung carcinoma), PA-1 (Ovarian cancer) and MCF-7 (Breast cancer), with standard as Doxorubicin. Moreover the antimicrobial activity on Staphylococcus aureus, Bacillus coagulans and one Gram-negative—Escherichia coli, human pathogenic bacteria; and three fungal strains—Aspergillus niger, Tricoderma viride and Fusarium oxysporum. Result: The results showed significant association of phytochemicals on inhibition of test bacteria and fungi with significant p value pTricoderma viride No Association Was Found P>0.05.},
 year = {2020}
}

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TY  - JOUR
T1  - In Vitro Cytotoxic Activity Toward Anticancer and Antimicrobial of Azadirachta Indica, Aegle Marmelos, Ocimum Sanctum and Withania Somnifera Extracts
AU  - Rajeev Nema
AU  - Sarita Khare
Y1  - 2020/09/30
PY  - 2020
N1  - https://doi.org/10.11648/j.be.20200402.11
DO  - 10.11648/j.be.20200402.11
T2  - Bioprocess Engineering
JF  - Bioprocess Engineering
JO  - Bioprocess Engineering
SP  - 40
EP  - 46
PB  - Science Publishing Group
SN  - 2578-8701
UR  - https://doi.org/10.11648/j.be.20200402.11
AB  - Background: Resistance to treatment represents the ‘big’ problem and the considerable improvement in survival rates still remains a researcher’s dream. Thus, continued research efforts are required to make treatments more personalized, to minimize side effects and improve overall survival and to also have an insight in toxico-genomics. Indeed proof of facts about medicinal plants worldwide and rich Indian medicinal flora, Objective: in the present investigation attempts to evaluate antimicrobials and anticancer therapeutic properties of isolated constituents from Withania somnifera (ASHWANGANDHA) Part Used Leaves, Aegle marmeleos (BEL) Part Used Leaves, Azadirachta indica (NEEM) Part Used Leaves, Ocimum sanctum (TULASI) Part Used Leaves, Method: Hydro alcoholic (1:1) Extracts were evaluated against cancer cell lines i.e. A549 (Lung carcinoma), PA-1 (Ovarian cancer) and MCF-7 (Breast cancer), with standard as Doxorubicin. Moreover the antimicrobial activity on Staphylococcus aureus, Bacillus coagulans and one Gram-negative—Escherichia coli, human pathogenic bacteria; and three fungal strains—Aspergillus niger, Tricoderma viride and Fusarium oxysporum. Result: The results showed significant association of phytochemicals on inhibition of test bacteria and fungi with significant p value pTricoderma viride No Association Was Found P>0.05.
VL  - 4
IS  - 2
ER  -

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